IP-cure-B clinical trial
Do you know that there is a clinical trial going on in the framework of the IP-cure-B project?
TheANRS HB07 clinical trial issponsored by ANRS | Emerging Infectious Diseasesand takes place in different centres across Europe involved in the project.
The objective of the EU-funded IP-cure-B project is to develop novel curative concepts for chronic hepatitis B (CHB). The project aims to improve the cure rate of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine. Researchers will also identify immune and viral biomarkers for monitoring patient stratification and treatment response. Integrating biological and clinical data will enable models for the best combination of treatment and effectiveness of novel curative therapies concerning disease spectrum and patient heterogeneity. The preclinical platform will be evaluated in humanised mice, combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses. Proof of concept will be obtained in a clinical trial of a combination of novel compounds stimulating innate immunity.
Outcomes for medical experts
The project aims at proposing a treatment paradigm shift with the development of novel combination therapies for CHB with improved cure rates and a better appraisal of novel biomarkers to improve patient selection for treatment and monitoring treatment response.
Outcomes for community
The development of such curative therapies with a finite duration of administration will pave the way towards a universal treatment of all individuals that suffer from chronic HBV infection. It is thus expected to result in a long-term reduction in cost and global burden of CHB (short-term therapy, increased treatment uptake in the infected population, decreased rate of liver complications and mortality).
Outcomes for patient
The project aims at designing and developing novel treatment strategies towards the cure of infection with a shorter duration of treatment. It is expected to result in improved quality of life and decreased social stigma.
| LIST OF CLINICAL TRIAL SITES | |||||
| HOSPITAL | HEAD OF DEPARTMENT | PRINCIPAL INVESTIGATOR | ADDRESS | ||
| Hospices Civils de Lyon (France) | Pr. Fabien ZOULIM [email protected] | Pr. Fabien ZOULIM [email protected] Telephone (secretary) : 04 26 10 93 55 Carrie Newsom, Study coordinator | Hepatology Department 103 Grande Rue de la Croix-Rousse 69004 Lyon France | ||
| UniversitatKlinikum in Freiburg (Germany) | Pr. Robert THIMME [email protected] | Pr. Robert THIMME [email protected] | Department of Internal Medicine Clinic for Internal Medicine II – Gastroenterology, Hepatology, Endocrinology and Infectiology Hugstetter Street 55 79106 Freiburg Germany | ||
| Hôpital Saint-Joseph (France) | Pr. Marc BOURLIERE [email protected] | Pr. Marc BOURLIERE [email protected] | Hepato-gastroenterology department 26 boulevard de Louvain 13285 Marseille Cedex 8 France | ||
| Fondazione IRCCS Ca’ GrandaOspedale Maggiore Policlinico in Milan (Italy) | Pr. Pietro LAMPERTICO [email protected] | Pr. Pietro LAMPERTICO [email protected] | Gastroenterology and Hepatology Division Via Francesco Sforza 35 20122 Milan Italy | ||
| University Hospital of Parma (Italy) | Pr. Ovidio BUSSOLAFI [email protected] | Pr. Carlo FERRARI [email protected] | Department of General and Specialized Medical AreaAziendaOspedalieraUniversitaria di Parma Via Gramsci 14 43126 Parma Italy | ||
| Hôpital Pitié Salpêtrière (France) | Pr. Dominique THABUT [email protected] | Pr. Vlad RATZIU [email protected] | Service towpath-gastroentérologie Hôpital Pitié Salpêtrière 47-83, boulevard de l’hôpital 75651 Paris cedex 13 France | ||
CHU Hôtel-Dieu, Nantes (France) | Dr Jérôme GOURNAY [email protected] | Dr Jérôme GOURNAY [email protected] | CHU Hôtel-Dieu Service d’hépato-gastro-entérologie Institut des Maladies de l’Appareil Digestif 1 place Alexis Ricordeau 44093 Nantes Cedex 01 France | ||
Vall d’Hebron University Hospital in Barcelona (Spain) | Pr. Maria BUTI [email protected] | Pr. Maria BUTI [email protected] | Internal Medicine and Hepatology Passeig de la Vall d’Hebron, 119 08035 Barcelona Spain | ||
Press contacts:
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ANRS | Emerging infectious Diseases: [email protected]