Post-Doctoral position
Cancer Research Center of Lyon – INSERM Unit 1052 Lyon, France
“Hepatitis B virus cure” program
The research laboratory on Viral Hepatitis at INSERM Unit 1052 (Cancer Research Center of Lyon –CRCL) is opening a Post-Doctoral position to work on its “HBV cure” program The Viral Hepatitis.
Team has a longstanding experience in the study of the mechanisms of HBV persistence and the identification of novel targets for antiviral therapy. The laboratory is looking for a motivated candidate to work on a project focused on the characterization of novel approaches to directly target the viral minichromosome, the so-called covalently closed circular DNA (cccDNA), responsible for HBV persistence in infected cells. In particular, the project is aimed at the investigation of the use of nuclease-based strategies to hit cccDNA.
The project is integrated in a wider, international program on “HBV cure”, in which the laboratory is actively involved (1, 2). Relevant in vitro and in vivo models for the study of human HBV infection and expertise in molecular virology and epigenetics are well established in the host laboratory. The candidate will also benefit from the scientific environment and technical platforms provided by the CRCL (http://www.crcl.fr). The position is available immediately.
The project is integrated in a wider, international program on “HBV cure”, in which the laboratory is actively involved (1, 2). Relevant in vitro and in vivo models for the study of human HBV infection and expertise in molecular virology and epigenetics are well established in the host laboratory. The candidate will also benefit from the scientific environment and technical platforms provided by the CRCL (http://www.crcl.fr). The position is available immediately.
The highly motivated candidate will have to hold a PhD and be experienced in cell culture and molecular biology. Experience in molecular virology and/or genome editing technology will be welcome.
The candidates should send their application (C.V., letter of motivation and 2 letters of recommendation) to:
Prof. Fabien Zoulim
Head of Viral Hepatitis Laboratory, INSERM U1052
e-mail: [email protected]; [email protected]
Prof. Fabien Zoulim
Head of Viral Hepatitis Laboratory, INSERM U1052
e-mail: [email protected]; [email protected]
References
1) Fanning GC, Zoulim F, Hou J, Bertoletti A. Therapeutic strategies for hepatitis B virus infection: towards a cure. Nat Rev Drug Discov. 2019
2) Martinez MG, Boyd A, Combe E, Testoni B, Zoulim F. Covalently closed circular DNA: the ultimate therapeutic target for curing Hepatitis B virus infections. J Hepatol. 2021
1) Fanning GC, Zoulim F, Hou J, Bertoletti A. Therapeutic strategies for hepatitis B virus infection: towards a cure. Nat Rev Drug Discov. 2019
2) Martinez MG, Boyd A, Combe E, Testoni B, Zoulim F. Covalently closed circular DNA: the ultimate therapeutic target for curing Hepatitis B virus infections. J Hepatol. 2021
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[b]Oscar R[/b]
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[b]Response[/b]
We are sorry about your experience ********. We always make sure that our quotes are as accurate as possible based on the items discussed in the move order. Most of our estimates that we provide to our customers are done so, over the phone. You and your sales representative built the estimate room by room to make sure that all your items were accounted for and recorded in writing, in your contract. After we build the estimate, we send it back to our customers for verification in order to make sure all their items are on the list. After the customer checks everything twice on the Move Order and on all goods we ALWAYS ask you to initial under the “Inventory Checkmark Spreadsheet” and “Inventory List Categorize by Room”. WE NEVER TAKE A DEPOSIT AND SCHEDULE THE MOVE BEFORE OUR CUSTOMER REVIEWS THE INVENTORY. Your move was then rescheduled. Original price was 5k for 128 items and it included everything. The price of 15k was for 2 full 26 ft trucks. After visual estimates, that our FOREMANS always do before starting the job, we counted over 280 items and offered the price of 9k. You canceled the move and told the guys to leave. Everytime a customer cancels their move because the price increased, we go over all recorded phone calls that we have had with the customer. This is to double check the accuracy of the estimate and the verbal agreement. I don’t want to blame you as a customer, but at the same time, be honest and respond fairly to our negative reviews. Our sales consultant did a great job and didn’t miss any item that was mentioned verbally and reviewed in print. All of our calls are recorded to ensure accuracy. If a customer never mentions more than half of the items that he actually has to move, we have no choice but to charge for the actual amount of labor and storage. I would however like to say we are sorry to everyone for what happened. Moving is a stressful business for all parties involved and some things don’t go as planned. If anyone reading this would like more information regarding this review, you can email me at *********@*********
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